Publications
2023
Direct tests of cytochrome c and c1 functions in the electron transport chain of malaria parasites.
Espino-Sanchez TJ, Wienkers H, Marvin RG, Nalder SA, García-Guerrero AE, VanNatta PE, Jami-Alahmadi Y, Mixon Blackwell A, Whitby FG, Wohlschlegel JA, Kieber-Emmons MT, Hill CP, Sigala PA.
Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2301047120. doi: 10.1073/pnas.2301047120. Epub 2023 May 1. PMID: 37126705
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase..
Hicks KG, Cluntun AA, Schubert HL, Hackett SR, Berg JA, Leonard PG, Ajalla Aleixo MA, Zhou Y, Bott AJ, Salvatore SR, Chang F, Blevins A, Barta P, Tilley S, Leifer A, Guzman A, Arok A, Fogarty S, Winter JM, Ahn HC, Allen KN, Block S, Cardoso IA, Ding J, Dreveny I, Gasper WC, Ho Q, Matsuura A, Palladino MJ, Prajapati S, Sun P, Tittmann K, Tolan DR, Unterlass J, VanDemark AP, Vander Heiden MG, Webb BA, Yun CH, Zhao P, Wang B, Schopfer FJ, Hill CP, Nonato MC, Muller FL, Cox JE, Rutter J.
Science. 2023 Mar 10;379(6636):996-1003. doi: 10.1126/science.abm3452. Epub 2023 Mar 9. PMID: 36893255
Direct Tests of Cytochrome Function in the Electron Transport Chain of Malaria Parasites.
Espino-Sanchez TJ, Wienkers H, Marvin RG, Nalder SA, García-Guerrero AE, VanNatta PE, Jami-Alahmadi Y, Blackwell AM, Whitby FG, Wohlschlegel JA, Kieber-Emmons MT, Hill CP, Sigala PA.
bioRxiv. 2023 Jan 23:2023.01.23.525242. doi: 10.1101/2023.01.23.525242. Preprint. PMID: 36747727
2022
Active conformation of the p97-p47 unfoldase complex.
Xu Y, Han H, Cooney I, Guo Y, Moran NG, Zuniga NR, Price JC, Hill CP, Shen PS.
Nat Commun. 2022 May 12;13(1):2640. doi: 10.1038/s41467-022-30318-3. PMID: 35552390
Ramiro IBL, Bjørn-Yoshimoto WE, Imperial JS, Gajewiak J, Salcedo PF, Watkins M, Taylor D, Resager W, Ueberheide B, Bräuner-Osborne H, Whitby FG, Hill CP, Martin LF, Patwardhan A, Concepcion GP, Olivera BM, Safavi-Hemami H.
Sci Adv. 2022 Mar 25;8(12):eabk1410. doi: 10.1126/sciadv.abk1410. Epub 2022 Mar 23. PMID: 35319982
Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Xiong X, Blakely A, Kim JH, Menting JG, Schäfer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun Ü, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH.
Nat Chem Biol. 2022 May;18(5):511-519. doi: 10.1038/s41589-022-00981-0. Epub 2022 Mar 14. PMID: 35289328
Connell Z, Parnell TJ, McCullough LL, Hill CP, Formosa T.
Nucleic Acids Res. 2022 Jan 25;50(2):784-802. doi: 10.1093/nar/gkab1262. PMID: 34967414
2021
Song A, Hazlett Z, Abeykoon D, Dortch J, Dillon A, Curtiss J, Martinez SB, Hill CP, Yu C, Huang L, Fushman D, Cohen RE, Yao T.
Elife. 2021 Nov 11;10:e72798. doi: 10.7554/eLife.72798. PMID: 34761751
Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.
Liu L, Tang M, Pragani R, Whitby FG, Zhang YQ, Balakrishnan B, Fang Y, Karavadhi S, Tao D, LeClair CA, Hall MD, Marugan JJ, Boxer M, Shen M, Hill CP, Lai K, Patnaik S.
J Med Chem. 2021 Sep 23;64(18):13551-13571. doi: 10.1021/acs.jmedchem.1c00945. Epub 2021 Sep 7. PMID: 34491744
Peptoid Residues Make Diverse, Hyperstable Collagen Triple-Helices
Kessler JL, Kang G, Qin Z, Kang H, Whitby FG, Cheatham TE 3rd, Hill CP, Li Y, Yu SM
J Am Chem Soc. 2021 Jul 28;143(29):10910-10919. doi: 10.1021/jacs.1c00708. Epub 2021 Jul 13. PMID: 34255504
Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal
Zheng Y, Schubert HL, Singh PK, Martins LJ, Engelman AN, D’Orso I, Hill CP, Planelles V
mBio 12:e01098-21. https://doi.org/10.1128/mBio.01098-21.
Sarabia I, Novis CL, Macedo AB, Takata H, Nell R, Kakazu JC, Furler RL, Shakya B, Schubert HL, Hill CP, DePaula-Silva AB, Spivak AM, Trautmann L, Planelles V, Bosque A.
Front Immunol. 2021 Jun 14;12:682182. doi: 10.3389/fimmu.2021.682182. eCollection 2021. PMID: 34194436
2020
Same structure, different mechanisms?
Tsai FTF, Hill CP
Elife. 2020 Apr 23;9:e56501. doi: 10.7554/eLife.56501. PMID: 32321627
2019
Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation
Han H, Schubert HL, McCullough J, Monroe N, Purdy MD, Yeager M, Sundquist WI, Hill CP
J Biol Chem. 2019 Nov 25;. doi: 10.1074/jbc.AC119.009890. PubMed, PMID: 31767681
Novel four-disulfide insulin analog with high aggregation stability and potency
Xiong X, Blakely A, Karra P, VandenBerg MA, Ghabash G, Whitby F, Zhang YW, Webber MJ, Holland WL, Hill CP, Danny CH
Proceedings of the Royal Irish Academy. Section B: Biological, geological, and chemical science. 2019 November
Characterization of resistance to a potent D‑peptide HIV entry inhibitor
Smith AR, Weinstock MT, Siglin AE, Whitby FG, Francis JN, Hill CP, Eckert DM, Root MJ and Kay MS
Retrovirology (2019) 16:28 10.1186/s12977-019-0489-7 PMID:31640718
Structure of the Cdc48 segregase in the act of unfolding an authentic substrate
Cooney I, Han H, Stewart MG, Carson RH, Hansen DT, Iwasa JH, Price JC, Hill CP, Shen PS
Science. 2019 Aug 2;365(6452):502-505. doi: 10.1126/science.aax0486. Epub 2019 Jun 27. PubMed PMID: 31249134
Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases
Han H, Fulcher JM, Dandey VP, Iwasa JH, Sundquist WI , Kay MS, Shen PS, Hill CP
Elife. 2019 Jun 11;8. pii: e44071. doi: 10.7554/eLife.44071. PMID:31184588
Selective kinase inhibition shows that Bur1 (Cdk9) phosphorylates the Rpb1 linker in vivo
Chun Y, Joo YJ, Suh H, Batot G, Hill CP, Formosa T, and Buratowski S
Mol. Cell. Biol. 2019 doi:10.1128/MCB.00602-18, PMID: 31085683
Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction with the ubiquitin receptor RPN13
Hemmis CW, Heard SC, Hill CP
J. Biol. Chem. 2019; 294(25) 9659–9665 DOI: 10.1128/MCB.00602-18, PMID: 31064842
Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4
Han H, Hill CP
Biochem Soc Trans. 2019 Jan 15 doi: 10.1042/BST20180260, PMID: 30647138
2018
Vms1p is a release factor for the ribosome-associated quality control complex
Zurita-Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J
Nat Commun. 2018 Jun 6;9(1):2197. doi: 10.1038/s41467-018-04564-3 PMID:29875445
2017
The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets
Han H, Monroe N, Sundquist WI, Shen PS, Hill CP
Elife. 2017 Nov. 22. 6:e31324. doi: 10.7554/eLife.31324. PMID: 29165244 PMCID: PMC5716660
Macromolecular Machines and Assemblies – Rise and Fall at the Molecular Level
Forest KT, Hill CP
Curr Opin Struct Biol. 2015 Apr; 31: vii–viii. doi: 10.1016/j.sbi.2015.05.005 PMID: 26027771, PMCID: PMC4878820
Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria
Nielson JR, Fredrickson EK, Waller TC, Rendón OZ, Schubert HL, Lin Z, Hill CP, Rutter J.
Mol Cell. 2017 68(4) 673-685.e6 doi: 10.7554/eLife.31324. PMID: 29149595 PMCID: PMC5716660
A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription
Sdano MA, Fulcher JM, Palani S, Chandrasekharan MB, Parnell TJ, Whitby FG, Formosa T, Hill CP
eLife 2017;6:e28723 doi: 10.7554/eLife.28723. PMID: 28826505 PMCID: PMC5599234
Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism
VanderLinden RT, Hemmis CW, Yao T, Robinson H, Hill CP
J Biol Chem. 2017 Apr 25. doi: 10.1074/jbc.M117.785287. PMID:28442575
Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
Monroe N, Han H, Shen PS, Sundquist WI, Hill CP
Elife. 2017 Apr 5;6. pii: e24487. doi: 10.7554/eLife.24487. PMID: 28379137
2016
Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines
Monroe N, Hill CP
J Mol Biol. 2016 May 8;428(9 Pt B):1897-911. doi: 10.1016 PMID:26555750
2015
FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs
Kemble DJ, McCullough LL, Whitby FG, Formosa T, Hill CP
Mol Cell. 2015 Oct 15;60(2):294-306
Editorial overview: Macromolecular machines and assemblies: Rise and fall at the molecular level
Forest KT, Hill CP
Curr Opin Struct Biol. 2015 Apr;31:vii-viii.
Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs)
Han H, Monroe N, Votteler J, Shakya B, Sundquist WI, Hill CP
J Biol Chem. 2015 May 22;290(21):13490-9
Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase
VanderLinden RT, Hemmis CW, Schmidt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP
Molecular Cell. 2015 57(5), March 5, 901-911
2014
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets
Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS.
Protein Sci. 2014 Oct 6
The Oligomeric State of the Active Vps4 AAA ATPase
Monroe N, Han H, Gonciarz MD, Eckert DM, Karren MA, Whitby FG, Sundquist WI, Hill CP
J. Mol. Biol 2014, 426(3) 510–525
2013
Building a Super Elongation Complex for HIV
Hill CP & Sundquist WI.
eLife. eLife 2:e00327.doi: 10.7554/eLife.00327
Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT
Kemble DJ, Whitby FG, Robinson H, McCullough LL, Formosa T, Hill CP.
J Biol Chem. (Epub ahead of print).
Structural Biology of the Proteasome
Kish-Trier E, Hill CP.
Annu Rev Biophys. 2013 May 6;42:29-49. doi: 10.1146/annurev-biophys-083012-130417. Epub 2013 Feb 13
Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler
Schubert HL, Wittmeyer J, Kasten MM, Hinata K, Rawling DC, Héroux A, Cairns BR, Hill CP.
PNAS 2013 Feb 26;110(9):3345-50
2012
Structure of a Proteasome Pba1-Pba2 Complex: IMPLICATIONS FOR PROTEASOME ASSEMBLY, ACTIVATION, AND BIOLOGICAL FUNCTION
Stadtmueller BM, Kish-Trier E, Ferrell K, Petersen CN, Robinson H, Myszka DG, Eckert DM, Formosa T, Hill CP.
J Biol Chem. 2012 Oct 26;287(44):37371-82 Epub 2012 Aug 28, PMCID: PMC3481334
Structure and function of the membrane deformation AAA ATPase Vps4
Hill CP, Babst M.
Biochim Biophys Acta. 2012 Jan;1823(1):172-81. Epub 2011 Sep 8.
2011
An asymmetric interface between the regulatory and core particles of the proteasome
Tian G, Park S, Lee MJ, Huck B, McAllister F, Hill CP, Gygi SP, Finley D.
Nat Struc Mtol Biol. 2011 Oct 30;18(11):1259-67. doi: 10.1038/nsmb.2147. PMCID: PMC3210322
Activation of the retroviral budding factor ALIX
Zhai Q, Landesman MB, Chung HY, Dierkers A, Jeffries CM, Trewhella J, Hill CP, Sundquist WI.
J Virol. 2011 Sep;85(17):9222-6. Epub 2011 Jun 29.
UNC119 is required for G protein trafficking in sensory neurons
Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W.
Nat Neurosci. 2011 Jun 5;14(7):874-80. doi: 10.1038/nn.2835.
Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain
Close D, Johnson SJ, Sdano MA, McDonald SM, Robinson H, Formosa T, Hill CP.
J Mol Biol. 2011 May 13;408(4):697-713. Epub 2011 Mar 17.
Proteasome activators
Stadtmueller BM, Hill CP.
Mol Cell. 2011 Jan 7;41(1):8-19. Review.
Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1
Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP.
J Virol. 2011 Jan;85(1):632-7. Epub 2010 Oct 20.
Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding
Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP.
PLoS One. 2011;6(12):e27466. Epub 2011 Dec 5.
2010
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes
Koirala S, Bui HT, Schubert HL, Eckert DM, Hill CP, Kay MS, Shaw JM.
J Cell Biol. 2010 Dec 13;191(6):1127-39.
Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding
McDonald SM, Close D, Xin H, Formosa T, Hill CP.
Mol Cell. 2010 Dec 10;40(5):725-35. Epub 2010 Nov 25.
Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance
Welch BD, Francis JN, Redman JS, Paul S, Weinstock MT, Reeves JD, Lie YS, Whitby FG, Eckert DM, Hill CP, Root MJ, Kay MS.
J Virol. 2010 Nov;84(21):11235-44. Epub 2010 Aug 18.
Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations
Schubert HL, Zhai Q, Sandrin V, Eckert DM, Garcia-Maya M, Saul L, Sundquist WI, Steiner RA, Hill CP.
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17951-6. Epub 2010 Sep 29.
X-ray structures of isopentenyl phosphate kinase
Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD.
ACS Chem Biol. 2010 May 21;5(5):517-27.
Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening
Sadre-Bazzaz K, Whitby FG, Robinson H, Formosa T, Hill CP.
Mol Cell. 2010 Mar 12;37(5):728-35.
Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma
Gangwal K, Close D, Enriquez CA, Hill CP, Lessnick
SL. Genes Cancer. 2010 Feb 1;1(2):177-187.
Structural models for interactions between the 20S proteasome and its PAN/19S activators
Stadtmueller BM, Ferrell K, Whitby FG, Heroux A, Robinson H, Myszka DG, Hill CP.
J Biol Chem. 2010 Jan 1;285(1):13-7. Epub 2009 Nov 4.
2009
Structural basis for ESCRT-III protein autoinhibition
Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI.
Nat Struct Mol Biol. 2009 Jul;16(7):754-62. Epub 2009 Jun 14.
X-ray structures of the hexameric building block of the HIV capsid
Pornillos O, Ganser-Pornillos BK, Kelly BN, Hua Y, Whitby FG, Stout CD, Sundquist WI, Hill CP, Yeager M.
Cell. 2009 Jun 26;137(7):1282-92. Epub 2009 Jun 11.
Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen
Phillips JD, Warby CA, Whitby FG, Kushner JP, Hill CP. J Mol Biol. 2009 Jun 5;389(2):306-14. Epub 2009 Apr 10.
J Mol Biol. 2009 Jun 5;389(2):306-14. Epub 2009 Apr 10.
2008
Biochemical and structural studies of yeast Vps4 oligomerization
Gonciarz MD, Whitby FG, Eckert DM, Kieffer C, Heroux A, Sundquist WI, Hill CP.
J Mol Biol. 2008 Dec 26;384(4):878-95. Epub 2008 Oct 4.
Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase
Schubert HL, Rose RS, Leech HK, Brindley AA, Hill CP, Rigby SE, Warren MJ.
Biochem J. 2008 Oct 15;415(2):257-63.
Structure and mechanistic implications of a uroporphyrinogen III synthase-product complex
Schubert HL, Phillips JD, Heroux A, Hill CP.
Biochemistry. 2008 Aug 19;47(33):8648-55. Epub 2008 Jul 24.
ALIX-CHMP4 interactions in the human ESCRT pathway
McCullough J, Fisher RD, Whitby FG, Sundquist WI, Hill CP.
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7687-91. Epub 2008 May 29.
Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa
Johnson SJ, Close D, Robinson H, Vallet-Gely I, Dove SL, Hill CP.
J Mol Biol. 2008 Apr 11;377(5):1460-73. Epub 2008 Feb 12.
Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p
Yu Z, Gonciarz MD, Sundquist WI, Hill CP, Jensen GJ.
J Mol Biol. 2008 Mar 21;377(2):364-77. Epub 2008 Jan 12.
Structural and functional analysis of the Spt16p N-terminal domain reveals overlapping roles of yFACT subunits
VanDemark AP, Xin H, McCullough L, Rawlins R, Bentley S, Heroux A, Stillman DJ, Hill CP, Formosa T.
J Biol Chem. 2008 Feb 22;283(8):5058-68. Epub 2007 Dec 18.
2007
Potent D-peptide inhibitors of HIV-1 entry
Welch BD, VanDemark AP, Heroux A, Hill CP, Kay MS.
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16828-33. Epub 2007 Oct 17.
Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein
Kelly BN, Kyere S, Kinde I, Tang C, Howard BR, Robinson H, Sundquist WI, Summers MF, Hill CP.
J Mol Biol. 2007 Oct 19;373(2):355-66. Epub 2007 Aug 15.
How to assemble a capsid
Sundquist WI, Hill CP.
Cell. 2007 Oct 5;131(1):17-9.
Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation
VanDemark AP, Kasten MM, Ferris E, Heroux A, Hill CP, Cairns BR.
Mol Cell. 2007 Sep 7;27(5):817-28.
Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding
Fisher RD, Chung HY, Zhai Q, Robinson H, Sundquist WI, Hill CP.
Cell. 2007 Mar 9;128(5):841-52.
A versatile platform for inactivation and destruction
Whitby FG, Hill CP.
Structure. 2007 Feb;15(2):137-8. No abstract available.
Two novel uroporphyrinogen decarboxylase (URO-D) mutations causing hepatoerythropoietic porphyria (HEP)
Phillips JD, Whitby FG, Stadtmueller BM, Edwards CQ, Hill CP, Kushner JP.
Transl Res. 2007 Feb;149(2):85-91.
2006
Structure of ATP-bound human ATP:cobalamin adenosyltransferase
Schubert HL, Hill CP.
Biochemistry. 2006 Dec 26;45(51):15188-96.
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain
Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI.
Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22.
Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278)
Kelly BN, Howard BR, Wang H, Robinson H, Sundquist WI, Hill CP.
Biochemistry. 2006 Sep 26;45(38):11257-66.
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release
Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI.
J Virol. 2006 Oct;80(19):9465-80.
Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes
Iwanczyk J, Sadre-Bazzaz K, Ferrell K, Kondrashkina E, Formosa T, Hill CP, Ortega J.
J Mol Biol. 2006 Oct 27;363(3):648-59. Epub 2006 Aug 9.
The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition
VanDemark AP, Blanksma M, Ferris E, Heroux A, Hill CP, Formosa T.
Mol Cell. 2006 May 5;22(3):363-74. Erratum in: Mol Cell. 2007 Jul 6;27(1):171-2.
2005
Purification and analysis of recombinant 11S activators of the 20S proteasome: Trypanosoma brucei PA26 and human PA28 alpha, PA28 beta, and PA28 gamma
Masters EI, Pratt G, Förster A, Hill CP.
Methods Enzymol. 2005;398:306-21.
Structural and mechanistic studies of VPS4 proteins
Scott A, Chung HY, Gonciarz-Swiatek M, Hill GC, Whitby FG, Gaspar J, Holton JM, Viswanathan R, Ghaffarian S, Hill CP, Sundquist WI.
EMBO J. 2005 Oct 19;24(20):3658-69. Epub 2005 Sep 29.
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing
Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL.
Science. 2005 Sep 2;309(5740):1534-9.
Ubiquitin-binding domains
Hicke L, Schubert HL, Hill CP.
Nat Rev Mol Cell Biol. 2005 Aug;6(8):610-21. Review.
The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions
Förster A, Masters EI, Whitby FG, Robinson H, Hill CP.
Mol Cell. 2005 May 27;18(5):589-99.
Crystal structure of the flagellar rotor protein FliN from Thermotoga maritima
Brown PN, Mathews MA, Joss LA, Hill CP, Blair DF.
J Bacteriol. 2005 Apr;187(8):2890-902.
E1 on the move
VanDemark AP, Hill CP.
Mol Cell. 2005 Feb 18;17(4):474-5. Review.
Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors
Rechsteiner M, Hill CP.
Trends Cell Biol. 2005 Jan;15(1):27-33. Review.
2004
Grabbing E2 by the tail.
VanDemark AP, Hill CP.
Nat Struct Mol Biol. 2004 Oct;11(10):908-9.
Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.
Phillips JD, Whitby FG, Warby CA, Labbe P, Yang C, Pflugrath JW, Ferrara JD, Robinson H, Kushner JP, Hill CP.
J Biol Chem. 2004 Sep 10;279(37):38960-8. Epub 2004 Jun 12.
Ubiquitin recognition by the human TSG101 protein.
Sundquist WI, Schubert HL, Kelly BN, Hill GC, Holton JM, Hill CP.
Mol Cell. 2004 Mar 26;13(6):783-9.
2003
Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase.
Phillips JD, Whitby FG, Kushner JP, Hill CP.
EMBO J. 2003 Dec 1;22(23):6225-33.
Proteasome degradation: enter the substrate.
Förster A, Hill CP.
Trends Cell Biol. 2003 Nov;13(11):550-3.
The pore of activated 20S proteasomes has an ordered 7-fold symmetric conformation.
Förster A, Whitby FG, Hill CP.
EMBO J. 2003 Sep 1;22(17):4356-64.
Structure and ubiquitin binding of the ubiquitin-interacting motif.
Fisher RD, Wang B, Alam SL, Higginson DS, Robinson H, Sundquist WI, Hill CP.
J Biol Chem. 2003 Aug 1;278(31):28976-84. Epub 2003 May 14.
Structures along the catalytic pathway of PrmC/HemK, an N5-glutamine AdoMet-dependent methyltransferase.
Schubert HL, Phillips JD, Hill CP.
Biochemistry. 2003 May 20;42(19):5592-9.
Structural insights into the catalytic mechanism of cyclophilin A.
Howard BR, Vajdos FF, Li S, Sundquist WI, Hill CP.
Nat Struct Biol. 2003 Jun;10(6):475-81.
Two-stepping with E1.
VanDemark AP, Hill CP.
Nat Struct Biol. 2003 Apr;10(4):244-6.
2002
Structural basis of ubiquitylation.
VanDemark AP, Hill CP.
Curr Opin Struct Biol. 2002 Dec;12(6):822-30. Review.
Structural diversity in metal ion chelation and the structure of uroporphyrinogen III synthase.
Schubert HL, Raux E, Matthews MA, Phillips JD, Wilson KS, Hill CP, Warren MJ.
Biochem Soc Trans. 2002 Aug;30(4):595-600. Review.
Crystal structure of the middle and C-terminal domains of the flagellar rotor protein FliG.
Brown PN, Hill CP, Blair DF.
EMBO J. 2002 Jul 1;21(13):3225-34.
Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex.
Whitby FG, Phillips JD, Hill CP, McCoubrey W, Maines MD.
J Mol Biol. 2002 Jun 21;319(5):1199-210.
The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase.
Schubert HL, Raux E, Brindley AA, Leech HK, Wilson KS, Hill CP, Warren MJ.
EMBO J. 2002 May 1;21(9):2068-75.
SUMO wrestling with specificity.
VanDemark AP, Hill CP.
Structure. 2002 Mar;10(3):281-2.
The 11S regulators of 20S proteasome activity.
Hill CP, Masters EI, Whitby FG.
Curr Top Microbiol Immunol. 2002;268:73-89. Review.
[Reprint available upon request. Email]
2001
Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase.
Phillips JD, Parker TL, Schubert HL, Whitby FG, Hill CP, Kushner JP.
Blood. 2001 Dec 1;98(12):3179-85.
Crystal structure of human uroporphyrinogen III synthase.
Mathews MA, Schubert HL, Whitby FG, Alexander KJ, Schadick K, Bergonia HA, Phillips JD, Hill CP.
EMBO J. 2001 Nov 1;20(21):5832-9.
Defining polyubiquitin chain topology.
Chan NL, Hill CP.
Nat Struct Biol. 2001 Aug;8(8):650-2. No abstract available.
Structure of a new crystal form of tetraubiquitin.
Phillips CL, Thrower J, Pickart CM, Hill CP.
Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):341-4.
2000
Structural basis for the activation of 20S proteasomes by 11S regulators.
Whitby FG, Masters EI, Kramer L, Knowlton JR, Yao Y, Wang CC, Hill CP.
Nature. 2000 Nov 2;408(6808):115-20.
Image reconstructions of helical assemblies of the HIV-1 CA protein.
Li S, Hill CP, Sundquist WI, Finch JT.
Nature. 2000 Sep 21;407(6802):409-13.
1999
Structure of the C-terminal domain of FliG, a component of the rotor in the bacterial flagellar motor.
Lloyd SA, Whitby FG, Blair DF, Hill CP.
Nature. 1999 Jul 29;400(6743):472-5.
Structural basis for the specificity of ubiquitin C-terminal hydrolases.
Johnston SC, Riddle SM, Cohen RE, Hill CP.
EMBO J. 1999 Jul 15;18(14):3877-87.
Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani.
Phillips CL, Ullman B, Brennan RG, Hill CP.
EMBO J. 1999 Jul 1;18(13):3533-45.
Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution.
Worthylake DK, Wang H, Yoo S, Sundquist WI, Hill CP.
Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):85-92. Epub 1999 Jan 1.
1998
Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes.
Whitby FG, Xia G, Pickart CM, Hill CP.
J Biol Chem. 1998 Dec 25;273(52):34983-91.
Crystal structure of human uroporphyrinogen decarboxylase.
Whitby FG, Phillips JD, Kushner JP, Hill CP.
EMBO J. 1998 May 1;17(9):2463-71.
Identification of an activation region in the proteasome activator REGalpha.
Zhang Z, Clawson A, Realini C, Jensen CC, Knowlton JR, Hill CP, Rechsteiner M.
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2807-11.
Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution.
Worthylake DK, Prakash S, Prakash L, Hill CP.
J Biol Chem. 1998 Mar 13;273(11):6271-6.
1997
Structure of the proteasome activator REGalpha (PA28alpha).
Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang Z, Rechsteiner M, Hill CP.
Nature. 1997 Dec 11;390(6660):639-43.
The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer.
Johnston SC, Whitby FG, Realini C, Rechsteiner M, Hill CP.
Protein Sci. 1997 Nov;6(11):2469-73.
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
Vajdos FF, Yoo S, Houseweart M, Sundquist WI, Hill CP.
Protein Sci. 1997 Nov;6(11):2297-307.
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.
Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP.
Science. 1997 Oct 31;278(5339):849-53.
Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators.
Realini C, Jensen CC, Zhang Z, Johnston SC, Knowlton JR, Hill CP, Rechsteiner M.
J Biol Chem. 1997 Oct 10;272(41):25483-92.
Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex.
Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC.
Biochemistry. 1997 Sep 2;36(35):10666-74.
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution.
Johnston SC, Larsen CN, Cook WJ, Wilkinson KD, Hill CP.
EMBO J. 1997 Jul 1;16(13):3787-96.
Molecular recognition in the HIV-1 capsid/cyclophilin A complex.
Yoo S, Myszka DG, Yeh C, McMurray M, Hill CP, Sundquist WI.
J Mol Biol. 1997 Jun 27;269(5):780-95.
Structures of wild-type chloromet and L103N hydroxomet Themiste zostericola myohemerythrins at 1.8 A resolution.
Martins LJ, Hill CP, Ellis WR Jr.
Biochemistry. 1997 Jun 10;36(23):7044-9.
Characterization and crystallization of human uroporphyrinogen decarboxylase.
Phillips JD, Whitby FG, Kushner JP, Hill CP.
Protein Sci. 1997 Jun;6(6):1343-6.
1996
Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.
Gamble TR, Vajdos FF, Yoo S, Worthylake DK, Houseweart M, Sundquist WI, Hill CP.
Cell. 1996 Dec 27;87(7):1285-94.
Comparison of the NMR and X-ray structures of the HIV-1 matrix protein: evidence for conformational changes during viral assembly.
Massiah MA, Worthylake D, Christensen AM, Sundquist WI, Hill CP, Summers MF.
Protein Sci. 1996 Dec;5(12):2391-8.
Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.
Hill CP, Worthylake D, Bancroft DP, Christensen AM, Sundquist WI.
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3099-104.
1995
Penicillin acylase has a single-amino-acid catalytic centre.
Duggleby HJ, Tolley SP, Hill CP, Dodson EJ, Dodson G, Moody PC.
Nature. 1995 Jan 19;373(6511):264-8.
1993
The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors.
Hill CP, Osslund TD, Eisenberg D.
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5167-71.
Crystal structure of a ubiquitin-dependent degradation substrate: a three-disulfide form of lysozyme.
Hill CP, Johnston NL, Cohen RE.
Proc Natl Acad Sci U S A. 1993 May 1;90(9):4136-40.
Complex of ribonuclease from Streptomyces aureofaciens with 2'-GMP at 1.7 A resolution.
Sevcik J, Hill CP, Dauter Z, Wilson KS.
Acta Crystallogr D Biol Crystallogr. 1993 Mar 1;49(Pt 2):257-71.
1991
Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.
Hill CP, Yee J, Selsted ME, Eisenberg D.
Science. 1991 Mar 22;251(5000):1481-5.
X-ray structure of an unusual Ca2+ site and the roles of Zn2+ and Ca2+ in the assembly, stability, and storage of the insulin hexamer.
Hill CP, Dauter Z, Dodson EJ, Dodson GG, Dunn MF.
Biochemistry. 1991 Jan 29;30(4):917-24.
1990
Crystal structure of alpha 1: implications for protein design.
Hill CP, Anderson DH, Wesson L, DeGrado WF, Eisenberg D.
Science. 1990 Aug 3;249(4968):543-6.
Expression, purification and crystallization of penicillin G acylase from Escherichia coli ATCC 11105.
Hunt PD, Tolley SP, Ward RJ, Hill CP, Dodson GG.
Protein Eng. 1990 Jul;3(7):635-9.
Pre-History
Protein crystallography: more surprises ahead.
Eisenberg D, Hill CP.
Trends Biochem Sci. Jul;14(7):260-4. Review. (1989)
Comparative Study of Microbial Ribonuclease Structures.
Hill, C.P.
Structure and Chemistry of Ribonucleases, A. Pavlovsky and K. Polyakov, eds, p. 171-179. (1989)
The 2-Zinc Insulin Hexamer is a Calcium Binding Protein.
Dunn, M.F., Palmieri, R., Kaarsholm, N.C., Roy, M., Lee, R.W.-K., Dauter, Z., Hill, C., Dodson, G.G.
Calcium Binding Proteins in Health and Disease, A.W. Norman, T.C. Vanamon and A. Means, eds., pp. 372-383 (1987)
The 2-Zinc Insulin Hexamer is a Calcium Binding Protein.
Dunn, M.F., Palmieri, R., Kaarsholm, N.C., Roy, M., Lee, R.W.-K., Dauter, Z., Hill, C., Dodson, G.G.
Calcium Binding Proteins in Health and Disease, A.W. Norman, T.C. Vanamon and A. Means, eds., pp. 372-383 (1987)
Structural Comparison of Some Microbial Ribonucleases.
Hill, C.P., Dodson, G.G., Borisova, S.N., Pavlovsky, A.G., Polyakov, K.M., Strokopytov, B.V. and Sevcik, J.
Metab. and Enzymology of Nucl. Acids 6:317-322 (1987)
The Structure and Catalytic Site of Microbial Ribonuclease.
Dodson, E.J., Dodson, G.G., Hill, C. and Mauguen, Y.
Metab. and Enzymology of Nucl. Acids 5:41-57 (1984)
The Structural and Sequence Homology of a Family of Microbial Ribonucleases.
Hill, C., Dodson, G., Heinemann, U., Saenger, W., Mitsui, Y., Nakamura, K., Borisov, S., Tischenko, G., Polyakov, K. and Pavlovsky, S.
Trends in Biochem. Sci. 8:364-369 (1983)